design, synthesis and molecular modeling studies of new 2,3-diaryl thiazolidine-4-ones as potential microtubule-binding agents

synthesis and docking studies of new 4-oxo-1,3-thiazolidine derivatives as potential anticonvulsant agents

Design and Synthesis of 4-flurophthalimides as potential anticonvulsant agents

Objective(s): Anticonvulsant activity of phthalimide was discovered in 2000 by molecular hybridization of thalidomide and ameltolide. In our previous research we have reported some new 4-substituted derivatives of phthalimide with good activity against the tonic and clonic seizures Material and Methods: A series of novel 4-flurophthalimides that designed using bioisosteric replacement were synt...

Design and Synthesis of 4-flurophthalimides as potential anticonvulsant agents

Objective(s): Anticonvulsant activity of phthalimide was discovered in 2000 by molecular hybridization of thalidomide and ameltolide. In our previous research we have reported some new 4-substituted derivatives of phthalimide with good activity against the tonic and clonic seizures Material and Methods: A series of novel 4-flurophthalimides that designed using bioisosteric replacement were synt...

design, synthesis, molecular modeling and biological evaluation of 1,2,4-triazine-5(4h)-ones as antitubulin agents

New Thiazolidine-4-ones of Ferulic Acid with Antioxidant Potential

New thiazolidine-4-one derivatives of ferulic acid have been synthesized in one step ("one-pot") by cyclization of ferulic acid hydrazide with different aromatic aldehydes and mercaptoacetic acid. The structure of the synthesized compounds was proved by infrared (IR) and nuclear magnetic resonance (H-NMR) spectroscopy. The in vitro antioxidant potential of the synthesized compounds was evaluate...

Design, Synthesis, Biological Evaluation and Molecular Modeling Study of Novel Indolizine-1-Carbonitrile Derivatives as Potential Anti-Microbial Agents

A novel one-pot two step tandem reaction for the synthesis of indolizine-1-carbonitrile derivatives (5a-i) was identified. The route comprises 1,3-dipolar cycloaddition reaction of aromatic aldehyde derivatives (1a-i), malononitrile (2) and 1-(2-(4-bromophenyl)-2-oxoethyl)-2-chloropyridin-1-ium (4) under ultrasound irradiation at room temperature in the presence of triethylamine at acetonitrile...